Journal of Depression and Anxiety
Open Access

Hengfen L

Publications

• Research Article
  Escitalopram Response in Panic Disorder is Not Associated with Three 5-HT1A Receptor Gene Polymorphisms (Rs6295, Rs10042486, or Rs1364043) in Chinese-Han Patients
  Author(s): Wenhui C, Qian L, Suxia C, Jianyue P and Hengfen L*Wenhui C, Qian L, Suxia C, Jianyue P and Hengfen L*
  
  Background: Prior studies have implicated 5-HT1A receptor gene (HTR1A) polymorphisms in the etiology of panic disorder (PD) as well as in the therapeutic response to selective serotonin reuptake inhibitors (SSRIs). A functional HTR1A C-1019G polymorphism (rs6295) in the promoter region and two non-synonymous polymorphisms (rs10042486 and rs1364043) were previously found to be associated with SSRI pharmacogenetics. However, no studies have examined this relationship in Chinese-Han PD patients. Methods: Seventy-seven patients with PD according to DSM-IV criteria were recruited. All of them with a minimum score of 8 on the seven item Panic Disorder Severity Scale, Chinese version (PDSS-CV). In this study, we evaluated the association between three single nucleotide polymorphisms (SNPs) of HTR1A (rs6295, rs10042486, and rs1364043) and the clinical .. View More»
  DOI: 10.4172/2167-1044.S12-006

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