Journal of Fertilization: In Vitro - IVF-Worldwide, Reproductive Medicine, Genetics & Stem Cell Biol
Open Access

Heather G. Huddleston

Publications

• Research Article
  FMR1 Repeats and Ovarian Reserve: CGG Repeat Number does not Influence Antral Follicle Count
  Author(s): Trimble LB Spitzer, Erica B. Johnstone, Heather G. Huddleston, Marcelle I. Cedars, Gina Davis and Victor Y. FujimotoTrimble LB Spitzer, Erica B. Johnstone, Heather G. Huddleston, Marcelle I. Cedars, Gina Davis and Victor Y. Fujimoto
  
  Background: Premature ovarian failure has been reported in women carrying FMR1 premutations. This study explored the association between number of FMR1 CGG repeats and Antral Follicle Count (AFC) in infertile women. Methods: Retrospective cross-sectional study; 350 infertile women underwent FMR1 genotyping and ultrasound for AFC at an academic reproductive medical center. Women with premature ovarian failure were excluded. FMR1 repeats were classified as Result(s): Only 1 woman carried a premutation, with 57 CGG repeats. Seven women carried intermediate alleles (<2%). FMR1 repeat number was not a significant predictor of AFC in an age-adjusted linear regression when the highest number allele or both allele members were included. Age-adjusted AFC did not differ between FMR1 groups by any of the classification systems.. View More»
  DOI: 10.4172/2165-7491.1000105

  Abstract PDF

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