Journal of Clinical and Cellular Immunology

Journal of Clinical and Cellular Immunology
Open Access

ISSN: 2155-9899

Heath M. Guay

Heath M. Guay
Immunology Research, Centocor R&D,
145 King of Prussia Rd, Mailstop R-4-1, Radnor, PA 19087

  • Review Article
    Role of IL-21 in Systemic Lupus Erythematosus
    Author(s): Sonia S. Jung and Heath M. GuaySonia S. Jung and Heath M. Guay

    Systemic lupus erythematosus is a chronic autoimmune disease that affects multiple organ systems and tissues. Activation and differentiation of autoreactive T and B cells, and the formation of pathogenic autoantibodies are central to disease pathogenesis. IL-21 is the most recently identified member of the family of cytokines whose receptors share the common γc. IL-21 is a pleotropic cytokine that regulates the activation, differentiation and expansion of B and T cells. Here, we review the role of IL-21 in T and B cell biology, and provide insight into the potential role of IL-21 in the development of SLE... Read More»
    DOI: 10.4172/2155-9899.S1-002

    Abstract PDF

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