Journal of Thyroid Disorders & Therapy
Open Access
ISSN: 2167-7948
+44 1300 500008
ISSN: 2167-7948
+44 1300 500008
Hayet Kaaroud
Department of Internal Medicine a Charles Nicole Hospital,
Boulevard 9 Avril, 1006 Bab Souika, Tunis
Case Report
Pulmonary Hemorrhage and Renal Involvement in Benzylthiouracil- Induced Vasculitis
Author(s): Hayet Kaaroud, Karima Boubaker, Karima Khiari, Hédi ben Maiz and Adel KhederHayet Kaaroud, Karima Boubaker, Karima Khiari, Hédi ben Maiz and Adel Kheder
Introduction: Vasculitis is a rare complication of antithyroid drugs reported with propylthiouracil, carbimazole, methimazole and Benzylthiouracil. Benzylthiouracil –induced Vasculitis are often severe forms with renal or pulmonary involvement, which can be life-threatening if left untreated .We describe the clinical course and medical management of 2 cases of severe vasculitis with alveolar hemorrhage and renal involvement occurred in 2 patients with Graves’ disease treated by Benzylthiouracil.
Cases report: A 36 and 33-year-old women with Graves’ disease developed alveolar hemorrhage and acute renal failure after respectively 36 and 144 months of Benzylthiouracil therapy. Kidney biopsy showed pauci-immune crescentic glomerulonephritis in the 2 cases. Anti Neutrophil Cytoplasmic Antibody (ANCA) was positive (P- ANCA in the.. View More»
DOI:
10.4172/2167-7948.1000114