Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Hatim FD
Biochemistry Research Laboratory, Central India Institute of Medical Sciences,
Nagpur- 440 010
India
Research Article
Mycobacterium Tuberculosis Heat Shock Protein 16 as a Potential Marker for Latent TB: A Preliminary Findings
Author(s): Rajpal SK, Snehal SW, Milind SP, Hemant JP, Girdhar MT and Hatim FDRajpal SK, Snehal SW, Milind SP, Hemant JP, Girdhar MT and Hatim FD
Identifying latent Tuberculosis (TB) is a key component of global efforts to eliminate TB. Heat shock proteins (Hsps) of mycobacteria are up regulated in response to various environmental stresses during infection. The present study was undertaken to evaluate the diagnostic efficacy of Mycobacterium Tuberculosis (MTB) Hsp16, MTB Hsp65 and MTB Hsp71 in latent and active TB in a high TB prevalence area by ELISA method. The mean optical density for Hsp16 as compared to Hsp65 and Hsp71 in latent TB subjects was significantly higher than the active subjects with significant P value of 0.0004. A preliminary finding indicates that the Hsp16 is more specific to latency and may be useful as a diagnostic marker for latent TB infection... View More»
DOI:
10.4172/2155-9899.1000115