Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
+44 1223 790975
ISSN: 2155-9899
+44 1223 790975
Hammadi A Alhilali
College of Medicine
Iraq
Research Article
Human Leukocyte Antigen-G and Certain Auto-antibodies Profile in Inflammatory Bowel Disease Patients
Author(s): Hammadi A Alhilali, Osama T Alobaidy and Abdul-Razzaq A TahirHammadi A Alhilali, Osama T Alobaidy and Abdul-Razzaq A Tahir
Inflammatory Bowel Disease (IBD) is a chronic inflammatory disorder of the bowel represented by two major forms; Ulcerative colitis (UC) and Crohn’s disease (CD). The idiopathic nature of this disease manifests due to irregular intestinal mucosal immune-tolerance. The present study evaluates a possible genetic predisposing factor of the soluble Human Leukocyte Antigen-G (HLA-G) and estimates the auto-antibodies in the sera of a group of IBD Iraqi patients (38 with UC and 16 with CD) during Nov. 2010-Sep. 2011. The sera of the entire experimental group have been examined using commercial ELISA kits. A group of 21 apparently healthy individuals was also included as a control group in this study. The s.HLA-G and Anti-Elastase auto-antibody have found to be produced in all (100%) of CD patients compared with 18 (47.4%) and 24 (63.2%) of UC patients, for the two tests, respectively. .. View More»
DOI:
10.4172/2155-9899.1000183