Organic Chemistry: Current Research
Open Access
ISSN: 2161-0401
+44 1478 350008
ISSN: 2161-0401
+44 1478 350008
Hamada S Abulkhair
Nasr City 11884, Cairo
Egypt
Research Article
Synthesis, Characterization and In Vitro Antitumor Evaluation of New Pyrazolo[3,4-d]Pyrimidine Derivatives
Author(s): Ahmed M El-Morsy, Mohamed S El-Sayed and Hamada S AbulkhairAhmed M El-Morsy, Mohamed S El-Sayed and Hamada S Abulkhair
A new series of 3-(methylthio)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine derivatives was synthesized. The antitumor activity of this series against human breast adenocarcinoma cell line MCF7 was evaluated. Out of twenty new derivatives, ten were revealed mild to moderate activity compared with doxorubicin as a reference antitumor. Among this new series N-(2-chlorophenyl)-2-(3-(methylthio)-4-oxo-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-5(4H)-yl)acetamide (13 a) was found the most active one with IC50 equal to µM.
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DOI:
10.4172/2161-0401.1000176