Journal of Glycobiology
Open Access

Greg Finn

Publications

• Review Article
  Role of HSGAGs in Regulation of FGF Signaling Pathway: Insights from Mathematical Modeling
  Author(s): Jitendra Kanodia and Greg FinnJitendra Kanodia and Greg Finn
  
  Signaling pathways act as relay systems that drive how biological systems respond to specific environmental cues. These cues act as regulators of how cells undergo biological processes like development and normal tissue homeostasis among others. Errors in environmental cues or the ability of cells to respond to such cues leads to erroneous cellular behavior and potentially disease states like cancer. Accordingly, insghts into cell-signaling and processing can be instrumental in design of effective therapies against malignancies. A central paradigm of signaling pathways is that ligands bind to and activate cell-membrane bound receptors, which in turn leads to activation of intracellular cascades. However, to target receptor mediated signaling effectively, it may not be enough to understand the biology of the target receptor in isolation. Interactions with other receptors of the same recep.. View More»
  DOI: 10.4172/2168-958X.1000113

  Abstract PDF

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