Clinical & Experimental Cardiology

Clinical & Experimental Cardiology
Open Access

ISSN: 2155-9880

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Ge Cao

Ge Cao


  • Research Article
    MIF Promoted Cardiovascular Angiogenesis via Erk/Mapk Pathway
    Author(s): Ge Cao, Jingxiu Fan, Hui Yu and Zejun ChenGe Cao, Jingxiu Fan, Hui Yu and Zejun Chen

    As the pivotal part of cardiovascular angiogenesis, endothelial cells dysfunction is the leading cause of cardiovascular diseases. Macrophage migration inhibitory factor (MIF) is a tumor growth factor with important roles in cervical tumor formation, invasion, progression and metastasis. However, there was no report on effect of MIF on endothelial cells is unclear, and it is still unknown whether MIF is associated with angiogenesis of endothelial cells. Our study was focused on the effect of MIF and PD98059 on endothelial cells HUVEC cell line, so as to investigate the influence of MIF on expression of vascular endothelial growth factor (VEGF). We also explored whether MIF will influence angiogenesis of endothelial cells via ERK/MAPK pathways. Endothelial cells HUVEC cells were conventionally cultured, and Western blot were used to detect the expression of MIF, ERK1 and VEGF .. View More»
    DOI: 10.4172/2155-9880.1000544

    Abstract PDF

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