Clinical & Experimental Cardiology
Open Access
ISSN: 2155-9880
ISSN: 2155-9880
Gad Keren
Department of Cardiology,
Tel-Aviv Sourasky Medical Center, Tel-Aviv, 64239
Israel
Research Article
Renal Failure is Associated with Driving of Gene Expression towards Cardiac Hypertrophy and Reduced Mitochondrial Activity
Author(s): Michal Entin-Meer, Metsada Pasmanik-Chor, Jeremy Ben-Shoshan, Sofia Maysel-Auslender, Pavel Goryainov, Ido Laron, Shelly Klipper, Varda Oron-Karni, Jonathan Semo, Einat Hertzberg and Gad KerenMichal Entin-Meer, Metsada Pasmanik-Chor, Jeremy Ben-Shoshan, Sofia Maysel-Auslender, Pavel Goryainov, Ido Laron, Shelly Klipper, Varda Oron-Karni, Jonathan Semo, Einat Hertzberg and Gad Keren
Background: The clinical concomitant presentation of cardiac and renal failure (RF) has been referred to as the “cardiorenal syndrome” (CRS), whereby acute or chronic dysfunction of one organ induces acute or chronic dysfunction of the other. To improve our understanding of the cellular and molecular mechanisms underlying the development and diversification of CRS we established a model for CRS and studied the unique gene expression patterns associated with this syndrome.
Methods and Results: We have utilized a rat model in which an acute myocardial infarction (AMI) was induced on the background of subtotal nephrectomy. Changes in cardiac functions and gene expression were analyzed as detailed below. The data demonstrate that chronic RF (CRF) enhances fibrosis of the cardiac tissue. The gene chip array data detect overexpression .. View More»
DOI:
10.4172/2155-9880.1000184