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Journal of Clinical and Cellular Immunology

Journal of Clinical and Cellular Immunology
Open Access

ISSN: 2155-9899

+44 1223 790975

Freja Aksel Jacobsen

Publications
  • Commentary
    B-cells and Inflammation in the Absence of the Abelson Related Gene (Arg)
    Author(s): Åsa Andersson and Freja Aksel JacobsenÅsa Andersson and Freja Aksel Jacobsen

    The Abelson non-receptor tyrosine kinases, c-Abl and Arg, are important regulators of cellular processes in cancer, inflammation, infection, and neuronal dynamics. Recent research on the role for these kinases in processes involving interactions with the cytoskeleton or signaling molecules, may lead to further insight into the pathogenesis of a variety of disorders, including chronic inflammatory diseases. In a mouse model for multiple sclerosis, we recently reported that Arg deficient mice develop T-cell mediated autoimmune neuro-inflammation with the same severity as littermate controls, but display a different B-cell phenotype upon immunization. Here we comment on these results and discuss the role for Arg in B-cell activation and homeostasis. .. View More»
    DOI: 10.4172/2155-9899.1000470

    Abstract PDF

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