Journal of Cancer Science and Research
Open Access
ISSN: 2576-1447
ISSN: 2576-1447
Frasia Oosthuizen
Saudi Arabia
Research Article
Efficacy and Safety of Aprepitant in Combination with Dexamethasone, Granisetron and Metoclopramide as a Prophylaxis of Chemotherapy-Induced Nausea and Vomiting in a Acute and Delayed Emesis in Arab Cancer Patient
Author(s): Iman Moustafa, Frasia Oosthuizen, Essam Badwey M and Abdulkarim CaraIman Moustafa, Frasia Oosthuizen, Essam Badwey M and Abdulkarim Cara
Background: Chemotherapy Induced Nausea and Vomiting (CINV) is one of the greatest sources of distress for patients. Severe CINV may force interruption of chemotherapy, it is important to control CINV to achieve successful chemotherapy.
Objective: This study to evaluate the efficacy and safety of aprepitant in a regimen containing aprepitant in combination with dexamethasone, granisetron and metoclopramide (APRDGM) versus a regimen dexamethasone, granisetron and metoclopramide (DGM) only, as a prophylaxis in (CINV) in highly emetogenic chemotherapy(HEC) in Arabic cancer patients.
Setting: This study was conducted at King Abdul-Aziz Medical city (Eastern Region, AlHasa, Saudi Arabia).
Methods: 309 patients all Arab population, treated with HEC, were enrolled in a retrospective, cohort stud.. View More»
DOI:
10.4172/2576-1447.1000107