Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
+44 1223 790975
ISSN: 2155-9899
+44 1223 790975
Françoise Mascart
Immunobiology Clinic, Hôpital Erasme, Université Libre de Bruxelles (U.L.B.),
Brussels
Belgium
Research Article
Immunological Signatures Identifying Different Stages of Latent Mycobacterium tuberculosis Infection and Discriminating Latent from Active Tuberculosis in Humans
Author(s): Kaatje Smits, Véronique Corbière, Violette Dirix, Leila Mekkaoui, Chloé Wyndham-Thomas, Myriam Libin, Alexandra Dreesman, Marc Loyens, Marie-Christine Payen, Mahavir Singh, Camille Locht and Françoise MascartKaatje Smits, Véronique Corbière, Violette Dirix, Leila Mekkaoui, Chloé Wyndham-Thomas, Myriam Libin, Alexandra Dreesman, Marc Loyens, Marie-Christine Payen, Mahavir Singh, Camille Locht and Françoise Mascart
Objectives: One third of the world population is considered latently infected with Mycobacterium tuberculosis (LTBI) and sterilizing this reservoir of bacteria that may reactivate is required for tuberculosis (TB) elimination. The group of individuals with LTBI is heterogeneous with some of them being more at risk to develop TB disease than others. Improved diagnosis of subjects with LTBI is needed, allowing to differentiate subjects with LTBI from those with active TB, and to select among LTBI subjects those who are more at risk to develop active TB. We have characterized at the cellular level both the quantitative and qualitative T cell responses to different mycobacterial antigens in selected populations of infected subjects in order to identify new biomarkers that could help to identify M. tuberculosis-infected subjects and to stratify them in ri.. View More»
DOI:
10.4172/2155-9899.1000341