Clinical & Experimental Cardiology
Open Access
ISSN: 2155-9880
+44 1300 500008
ISSN: 2155-9880
+44 1300 500008
Fanggang Cai
The First Affiliated Hospital of Fujian Medical University,
20 Chazhong Road, Fuzhou 350005
Indiana
Research Article
Pathologic changes of pancreatic endothelial cells in Diabetic Rat
Author(s): Jie Wu, Xiaorong Wang, Shao Dan Feng, Quwen Li and Fanggang CaiJie Wu, Xiaorong Wang, Shao Dan Feng, Quwen Li and Fanggang Cai
Aim: The study is to explore the relationship between pancreas endothelial cell injury and diabetes.
Methods: To induce with a single intraperitoneal injection of streptozotocin (STZ) for diabetic animal models, and collected the blood after 8 weeks, the level of Angiogenin-1 (Ang-1) and its receptor (Tie-2), vascular cell adhesion molecule-1 (VCAM-1) were determinated by ELISA method, histopathological examination of the pancreas, and observed pathological conditions of the pancreas endothelial cell injury in the models.
Results: The results showed that the level of ang-1, tie-2 and VCAM-1 were 585.04 ± 45.32 (pg/ml), 2399.40 ± 124.85 (pg/ml), 117.69 ± 12.34 (μg/L) in the Diabetes groups which were higher than that in control groups 551.29 ± 31.86 (pg/ml), 2103.27 ± 152.89 (pg/ml) a.. View More»
DOI:
10.4172/2155-9880.1000552