Journal of Clinical and Cellular Immunology

Journal of Clinical and Cellular Immunology
Open Access

ISSN: 2155-9899

+44 1223 790975

Estibalitz Laresgoiti-Servitje

Estibalitz Laresgoiti-Servitje
TEC-ABC School of Medicine, American British Cowdray Medical Center,
Carlos Graef Fernández 154-114 Mexico City, 05300

  • Review Article
    Pregnancy-Related MiRNAs Participate in the Regulation of the Immune System during the Gestational Period
    Author(s): Estibalitz Laresgoiti-ServitjeEstibalitz Laresgoiti-Servitje

    Pregnancy is a wonderful and complex example of immunomodulation. The regulation that occurs during pregnancy involves hormones, major histocompatibility molecules, cytokines and different types of cells. Recent evidence shows a significant role for miRNAs in the regulation of the immune system´s cells during the gestational period. Placental miRNAs, found in both normal and complicated pregnancies, are primarily localized in four clusters. These are the chromosome 19-miRNA cluster (C19MC), the miR-371-3 cluster (also on chromosome 19), the chromosome 14-miRNA cluster (M14MC), and the miR-17-92 cluster. Pregnancy-associated miRNAs may be involved in angiogenesis, trophoblast differentiation, and in the regulation of the immune system. However, their role has not been clearly elucidated. miRNAs hold promise as biomarkers in clinical settings, as altered miRNA expression ma.. View More»
    DOI: 10.4172/2155-9899.1000361

    Abstract PDF

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