Journal of Clinical and Cellular Immunology
Open Access

Estibalitz Laresgoiti-Servitje

Publications

• Review Article
  Pregnancy-Related MiRNAs Participate in the Regulation of the Immune System during the Gestational Period
  Author(s): Estibalitz Laresgoiti-ServitjeEstibalitz Laresgoiti-Servitje
  
  Pregnancy is a wonderful and complex example of immunomodulation. The regulation that occurs during pregnancy involves hormones, major histocompatibility molecules, cytokines and different types of cells. Recent evidence shows a significant role for miRNAs in the regulation of the immune system´s cells during the gestational period. Placental miRNAs, found in both normal and complicated pregnancies, are primarily localized in four clusters. These are the chromosome 19-miRNA cluster (C19MC), the miR-371-3 cluster (also on chromosome 19), the chromosome 14-miRNA cluster (M14MC), and the miR-17-92 cluster. Pregnancy-associated miRNAs may be involved in angiogenesis, trophoblast differentiation, and in the regulation of the immune system. However, their role has not been clearly elucidated. miRNAs hold promise as biomarkers in clinical settings, as altered miRNA expression ma.. View More»
  DOI: 10.4172/2155-9899.1000361

  Abstract PDF

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