Clinical & Experimental Cardiology

Clinical & Experimental Cardiology
Open Access

ISSN: 2155-9880

+44 1300 500008

Ernest C Madu

Ernest C Madu


  • Research Article
    Diagnostic Potential of miRNAs and their Correlation with High Sensitivity Troponin-I Levels in ACS- NSTEMI Patients
    Author(s): Charan Reddy KV and Nitin S GokhaleCharan Reddy KV and Nitin S Gokhale

    Background: High-sensitivity cardiac troponins (hs-cTns) are used as biomarkers for Acute Myocardial Infarction (AMI). However, hs-cTn levels are not specific and increase in other diseases that are not associated with AMI. Studies have shown that circulating micro RNAs (miRNAs) vary between different types of Acute Coronary Syndrome (ACS) patients. The main objectives of our study are: 1) To measure circulating miRNA-208a (miR-208a) and miRNA-499 (miR-499) in suspected AMI cases in Acute Coronary Syndrome-Non-ST-segment Elevated Myocardial Infarction (ACS-NSTEMI) patients, 2) To determine the time of release of these miRNAs and compare with hs-cTnI, and 3) To evaluate prognostic significance of miR-208a and miR-499 in early prediction of AMI. Methods: Serum miRNAs were isolated from suspected AMI patients (n=60) and non-ACSNSTEMI chest pain p.. View More»

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