Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Ekaterina Kulchavenya
Novosibirsk Research TB Institute, Novosibirsk Medical University,
Serbia
Review Article
Innate and Acquired Response on Tuberculosis
Author(s): Ekaterina KulchavenyaEkaterina Kulchavenya
Tuberculosis (TB) is a leading cause worldwide of human mortality attributable to a single infectious agent; nevertheless, the infection of human organism with Mycobacterium tuberculosis (Mtb) doesn’t lead to disease obligatory, by all means. Recent studies have revealed numerous polymorphisms implicated in host susceptibility to TB. Human organism may have an innate resistance to MTB. A hallmark of Mtb infection is the ability of most (90- 95%) healthy adults to control infection through acquired immunity, in which antigen specific T cells and macrophages arrest growth of Mtb bacilli and maintain control over persistent bacilli. Mtb induces vigorous immune responses, yet evades host immunity, persisting within phagosomes of the infected macrophages. Each stage of the host response to Mtb is under genetic control, including the initial encounter with MTB by macrophages, epitheli.. View More»
DOI:
10.4172/2155-9899.S13-005