Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
+44 1223 790975
ISSN: 2155-9899
+44 1223 790975
Einas M Al-Harbi
Molecular Genetics Laboratory, Kuwait Medical Genetics Center Center,
Ministry of Health-State of Kuwait
Kuwait
Research Article
DRB1*04 and DQB1*03 Alleles are Very Prevalent in Bahraini Families with Both T2DM and T1DM
Author(s): Einas M Al-Harbi, Eman M Farid, Fayza A Junaid, Jaipaul Singh and Khalid A GumaaEinas M Al-Harbi, Eman M Farid, Fayza A Junaid, Jaipaul Singh and Khalid A Gumaa
Objectives: Several investigations in families with both T1DM and T2DM have been reported to elucidate the genetic interaction between T1DM and T2DM and the clinical consequences for both diseases. The frequent occurrence of T1DM in relatives of patients with T2DM has also been previously observed. This study investigated whether the T2DM parent/grandparents share a specific HLA class II-DRB1and DQB1 alleles and their haplotype combination with the T1DM child. Methods: Twenty four Bahraini families with a T1DM child and either parents or grandparents with T2DM and with no family history of T1DM were selected. HLA class II-DRB1 and DQB1 were examined by SSP-PCR method and the distribution was analyzed. Results: In relation to DRB1*, the most common shared allele was DRB1*04:01:01 83% (n=20), whi.. View More»
DOI:
10.4172/2155-9899.1000309