Journal of Thyroid Disorders & Therapy
Open Access

Eduardo Anselmo Garcia., PhD

Publications

• Research Article
  Pro and Anti-Angiogenic Vascular Endothelial Growth Factors Expression in Benign and Malignant Thyroid Lesions
  Author(s): Eduardo Anselmo Garcia, Kleber Sim?es, Alda Wakamatsu, Cinthya dos Santos Cirqueira, Ven?ncio Avancini Ferreira Alves, Adhemar Longatto-Filho, PMIAC, Roberto Souza Camargo Eduardo Anselmo Garcia, Kleber Sim?es, Alda Wakamatsu, Cinthya dos Santos Cirqueira, Ven?ncio Avancini Ferreira Alves, Adhemar Longatto-Filho, PMIAC, Roberto Souza Camargo
  
  Vascular endothelial growth factors are the most powerful molecules related to angiogenesis and lymph angiogenesis stimulation and are frequently associated to a worse prognosis in many malignancies. Currently, anti-angiogenic VEGF-A165b has been described and it have been demonstrated to efficiently block the angiogenic sprout. We sought to investigate the VEGF family members expression involved with angiogenesis (including the anti-angiogenic VEGF-A165b) and lymph angiogenesis. The casuistic was composed by 196 cases. The frequencies of thyroid lesions were: 53 (27%) goitres, 16 (8%) thyroiditis, 9 (5%) follicular adenomas, 84 (43%) papillary carcinomas, and 34 (17%) follicular carcinomas. The immunohistochemical reactions for VEGF-A, VEGF-A165b, VEGF-B, VEGF-C and VEGF-D were performed and semi-quantitatively assessed. We observed a widespread positive immunoexpression of VEGF-A an.. View More»
  DOI: 10.4172/2167-7948.1000123

  Abstract PDF

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