Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
+44 1223 790975
ISSN: 2155-9899
+44 1223 790975
Éric Toussirot
Centre d’Investigation Clinique Biothérapie CBT-506, bâtiment St Joseph,
CHRU Place St Jacques, 25000 Besançon
France
Research Article
Peripheral Blood B cell Subsets and BAFF/APRIL Levels and their Receptors are Disturbed in Rheumatoid Arthritis but not in Ankylosing Spondylitis
Author(s): Béatrice Gaugler, Caroline Laheurte, Ewa Bertolini, Aurore Pugin, Daniel Wendling, Philippe Saas and Éric ToussirotBéatrice Gaugler, Caroline Laheurte, Ewa Bertolini, Aurore Pugin, Daniel Wendling, Philippe Saas and Éric Toussirot
Background: To evaluate the distribution of circulating B cell subsets and their expression of BAFF/APRIL receptors (BAFF-R, TACI and BCMA) as well as circulating levels of BAFF and APRIL in patients with rheumatoid arthritis (RA) or ankylosing spondylitis (AS) compared to healthy controls (HC).
Methods: 59 patients with RA, 61 patients with AS and 61 HC were evaluated. All patients were receiving traditional treatments and had not received prior biological treatment. Peripheral blood B cell subsets were assessed using multicolor flow cytometry using CD27, CD38 and IgD staining. Expression of BAFF-R, TACI and BCMA was analyzed on each cell subset.
Results: Distribution of peripheral B cells subsets was disturbed in RA compared to HC, with a decreased proportion of naïve and transitional B cells (p<0.005), whereas.. View More»
DOI:
10.4172/2155-9899.1000163