Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
+44 1223 790975
ISSN: 2155-9899
+44 1223 790975
David N. Irani
University of Michigan Medical School, 4007 Biomedical Sciences Research Building,
109 Zina Pitcher Place, Ann Arbor, MI 40109-2200
Tanzania
Review Article
Regulated Production of CXCL13 within the Central Nervous System
Author(s): David N. IraniDavid N. Irani
The chemokine, C-X-C motif ligand 13 (CXCL13), is constitutively expressed in lymphoid organs and controls the recruitment and compartmentalization of lymphocytes and antigen presenting cells within these specialized structures. Recent data, however, also show induction of this molecule under a variety of circumstances during central nervous system (CNS) inflammation. While its role(s) in the pathogenesis of neoplastic, infectious and autoimmune disorders of the CNS remain incompletely understood, growing evidence suggests that CXCL13 could become a relevant therapeutic target in at least some of these conditions. This review focuses on the diseases, cellular sources and external factors known to regulate CXCL13 production in the inflamed CNS.
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DOI:
10.4172/2155-9899.1000460