Journal of Clinical and Cellular Immunology

Journal of Clinical and Cellular Immunology
Open Access

ISSN: 2155-9899

+44 1223 790975

David G Hancock

David G Hancock
School of Medicine,
South Australia

  • Review Article
    The Peripheral Lymphatics as an Active Player in the Immune Response
    Author(s): David G Hancock, Tessa M Potezny and Patrick M WhiteDavid G Hancock, Tessa M Potezny and Patrick M White

    The lymphatics system has many diverse roles in the human body. These range from regulating fluid balance and fatty acid transport to serving as a conduit for leukocyte entry into lymphoid organs. While stromal cell populations are becoming increasingly recognised as important components of the immune response, the peripheral lymphatics are still commonly perceived as a passive conduit for immune cells. In contrast to this paradigm, the lymphatics are capable of responding to a wide range of pathogenic stimuli and secondary immune mediators, activating diverse, functional and stimulus dependant programs to these, with subsequent regulation of the effector function of multiple immune cell populations. In this review, we highlight papers that support the peripheral lymphatics as a crucial and active player in the immune response. We also interpret this evide.. View More»
    DOI: 10.4172/2155-9899.1000268

    Abstract PDF

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