Journal of Clinical Chemistry and Laboratory Medicine
Open Access

Danielle M Gualandro

Publications

• Research Article
  Direct Comparison of High-Sensitivity Cardiac Troponin T and I for Prediction of Mortality in Patients with Pneumonia
  Author(s): Dayana Flores, Joan Walter, Desiree Wussler, Nikola Kozhuharov, Albina Nowak, Julia Dinort, Patrick Badertscher, Jasmin Martin, Zaid Sabti, Jeanne du Fay de Lavallaz, Thomas Nestelberger, Jasper Boeddinghaus, Tobias Zimmermann, Luca Koechlin, Bettina Glatz, Rafal Czmok, Eleni Michou, Danielle M Gualandro, Tobias Breidthardt and Christian MuellerDayana Flores, Joan Walter, Desiree Wussler, Nikola Kozhuharov, Albina Nowak, Julia Dinort, Patrick Badertscher, Jasmin Martin, Zaid Sabti, Jeanne du Fay de Lavallaz, Thomas Nestelberger, Jasper Boeddinghaus, Tobias Zimmermann, Luca Koechlin, Bettina Glatz, Rafal Czmok, Eleni Michou, Danielle M Gualandro, Tobias Breidthardt and Christian Mueller
  
  Objectives: The primary objective was to directly compare the prognostic accuracy of hs-cTnT versus hs-cTnI for the prediction of death in patient with pneumonia. Methods: The prognostic accuracy of high sensitivity (hs)-cTnT and hs-cTnI was directly compared among patients presenting with dyspnea to the emergency department and centrally adjudicated by two independent experts to have pneumonia. Blood samples for the blinded measurement of hs-cTnT and hs-cTnI, as well as NTproBNP were obtained at ED presentation. CURB-65 was calculated as the multivariate risk score recommended in current guidelines. Primary endpoints were all-cause and cardiovascular (CV) mortality at 1 year. Results: Among 306 patients, median age was 75 years, 38% were women, with extensive comorbidities including chronic obstructive pulmonary disea.. View More»
  

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