Journal of Molecular Imaging & Dynamics

Journal of Molecular Imaging & Dynamics
Open Access

ISSN: 2155-9937

+44 20 3868 9735

Daniel Y. Lee

Daniel Y. Lee

Department of Radiology, The Methodist Hospital Research Institute, Houston, USA

In an effort to devise schemes to site-specifically deliver drugs “on demand” we have leveraged the inducible expression properties of the well-characterized class of stress-response factors, the heat shock proteins. We asked whether a small molecule ligand selective for such proteins could be used as a potential theranostic platform. By conjugating a fluorescent dye to a recently identified nucleoside analog with modest affinity for heat shock protein 70 (HSP70), we have found that cellular uptake can be enhanced following transient heat shock in vitro
Research Interest

Dr. Daniel Y. Lee research interest includes Heat shock proteins, Targeted drug delivery, Molecular targeting.

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