Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
+44 1223 790975
ISSN: 2155-9899
+44 1223 790975
Damalie Nakanjako
Makerere University College of Health Sciences and Infectious Diseases Institute,
P.O. Box 25308, Kampala
Uganda
Research Article
CD4 T-cell Activation and Reduced Regulatory T-cell Populations are Associated with Early Development of Cataracts among HIV-infected Adults in Uganda
Author(s): Damalie Nakanjako, Juliet Otiti-Sengeri, Isaac Ssewanyana, Rose Nabatanzi, Lois Bayigga, Samuel Kirimunda, Moses Joloba, Yukari C Manabe, Andrew Kambugu, Robert Colebunders and Harriet Mayanja-KizzaDamalie Nakanjako, Juliet Otiti-Sengeri, Isaac Ssewanyana, Rose Nabatanzi, Lois Bayigga, Samuel Kirimunda, Moses Joloba, Yukari C Manabe, Andrew Kambugu, Robert Colebunders and Harriet Mayanja-Kizza
Background: Cataracts contribute 12% of visual loss among HIV-infected adults (HIV-positive) in Uganda. Immuno-pathogenesis of cataracts may differ among HIV-negative and HIV-positive individuals; thus the need for innovative therapeutic interventions for cataracts among HIV-positive adults. We compared the regulatory T-cell (Treg) dysfunction among HIV-positive-with-cataracts, HIV-negative-with-cataracts and respectively age-matched HIV-healthy-volunteers.
Methods: In a laboratory based case-control study, nested within a clinical/surgical community outreach camp, within the Rakai Health Sciences Program (RHSP) rural cohort, 50 adults with cataracts eligible for surgery were selected consecutively. Routine provider-initiated HIV testing was done for individuals with unknown HIV sero-status. Peripheral Blood Mononuclear Cells (PBMC) were colle.. View More»
DOI:
10.4172/2155-9899.1000186