Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
+44 1223 790975
ISSN: 2155-9899
+44 1223 790975
Cornelia Halin
Institute of Pharmaceutical Sciences,
ETH Zurich, Wolfgang-Pauli Str. 10, HCI H413, CH-8093 Zurich
Switzerland
Review Article
Lymphatic Vessels in Inflammation
Author(s): Martina Vranova and Cornelia HalinMartina Vranova and Cornelia Halin
Lymphatic vessels are important for tissue fluid homeostasis and for the uptake of dietary lipids in the intestine. Moreover, lymphatic vessels are intimately linked with induction of the immune response, as they transport antigen, inflammatory mediators, and leukocytes from peripheral tissues to draining lymph nodes (dLNs). Research of the last 10 years has revealed that lymphatic vessels form a highly plastic network, which rapidly adapts to inflammation in a stimulus- and tissue-specific manner. The inflammatory environment induces changes in gene expression in lymphatic endothelial cells (LECs) and leads to a profound proliferative expansion of the lymphatic network in both the inflamed tissue and the dLNs. Inflammatory changes in the lymphatic network have been shown to impact fluid drainage as well as leukocyte trafficking, suggesting that lymphatic vessels play an active role i.. View More»
DOI:
10.4172/2155-9899.1000250