Journal of Fertilization: In Vitro - IVF-Worldwide, Reproductive Medicine, Genetics & Stem Cell Biol
Open Access
ISSN: 2375-4508
+44 1478 350008
ISSN: 2375-4508
+44 1478 350008
Clara Esteban-Pérez
Colombian Center of Fertility and Sterility,
CECOLFES, Bogota
Colombia
Research Article
Accumulation of Microsatellite Instability in Superoxide Dismutase-1 Knockout Mice: A Possible Predictor of Germ Cell Development or Tumorigenesis
Author(s): Harold Moreno-Ortiz, Clara Esteban-Pérez, Elkin Lucena, Nancy A Reichert and Dwayne A WiseHarold Moreno-Ortiz, Clara Esteban-Pérez, Elkin Lucena, Nancy A Reichert and Dwayne A Wise
The superoxide dismutase 1 gene (Sod1) is one of the cell protective mechanisms to eliminate reactive oxygen species damage in order to protect cell components and avoid germinal failure or tumorigenesis. Mouse primordial germinal cells are a population of cells originating from the proximal margin of the epiblast in close proximity to the extra embryonic ectoderm, and from which some cells differentiate into male or female germinal cells. During cell migration across the genital ridge, primordial germinal cells display an extensive proliferation rate and they are exposed to ROS damage. In absence of cell antioxidant mechanisms, primordial germinal cells have increased risk to accumulate specific mutations by free radical damage. We hypothesize that during cell migration, Sod1 knockout primordial germinal cells accumulate microsatellite instability and this could be a signal for primo.. View More»
DOI:
10.4172/2375-4508.1000144