Journal of Depression and Anxiety
Open Access
ISSN: 2167-1044
+44 1223 790975
ISSN: 2167-1044
+44 1223 790975
Cintly Celis-deHoyos
Tanzania
Research Article
Ziprasidone in Pediatric Bipolar Disorder: A 6-Week, Open-Label Comparison of Rapid vs. Slow Dose Titration
Author(s): Kirti Saxena, Annie Walley, Alex Simmons, Paul A. Nakonezny, Cintly Celis-deHoyos, Taryn Mayes, Cheryl L Person and Graham EmslieKirti Saxena, Annie Walley, Alex Simmons, Paul A. Nakonezny, Cintly Celis-deHoyos, Taryn Mayes, Cheryl L Person and Graham Emslie
Objective: This open- label clinical trial evaluated the dosing, safety, and effectiveness of rapid vs. slow titration of ziprasidone in pediatric bipolar disorder over a period of 6 weeks.
Methods: Study participants (aged 10-17 years) were diagnosed with bipolar disorder using standardized diagnostic instruments. Additionally, standardized rating scales were used to assess changes in mood, adverse effects, and overall functioning. Twenty-eight participants were randomly assigned to either the rapid- or slow-dose titration of ziprasidone. Linear mixed model analyses of repeated measures—adjusting for the age and respective baseline clinical score— were used to evaluate the main effects and the 2-way interaction effect (incorporating titration group and time). Cox Proportional Hazards Regression, adj.. View More»
DOI:
10.4172/2167-1044.1000130