Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Christian Pasquali
OM Pharma SA Geneva, Rue du Bois-du-Lan 22,
1217 Meyrin, Geneva
Switzerland
Research Article
Biomarkers Induced by the Immunomodulatory Bacterial Extract OM-85: Unique Roles for Peyer’s Patches and Intestinal Epithelial Cells
Author(s): Vania Manolova, Anna Flace, Patricia Jeandet, Wolfgang C Bessler and Christian PasqualiVania Manolova, Anna Flace, Patricia Jeandet, Wolfgang C Bessler and Christian Pasquali
Objective: The orally administered bacterial lysate OM-85 (Broncho-Vaxom®, Broncho-Munal®, Ommunal®, Paxoral®, Vaxoral®) is known to protect against recurrent respiratory tract infections. Despite mechanistic investigations performed during clinical and pre-clinical studies, little is known regarding the initial immune response to OM-85 following its passage through the stomach. To better understand the primary steps in the OM-85 gut-mediated immune-response cascade, we investigated its effects on two candidate cell types: intestinal epithelial cells (IECs) and Peyer’s patch (PP) leukocytes and confirmed its sustained immune effect in a reconstituted gastric buffer.
Methods: In order to confirm OM-85’s continued activity following gastric transit, THP-1 cells.. View More»
DOI:
10.4172/2155-9899.1000494