Journal of Clinical and Cellular Immunology
Open Access

Christian Pasquali

Publications

• Research Article
  Biomarkers Induced by the Immunomodulatory Bacterial Extract OM-85: Unique Roles for Peyer’s Patches and Intestinal Epithelial Cells
  Author(s): Vania Manolova, Anna Flace, Patricia Jeandet, Wolfgang C Bessler and Christian Pasquali Vania Manolova, Anna Flace, Patricia Jeandet, Wolfgang C Bessler and Christian Pasquali
  
  Objective: The orally administered bacterial lysate OM-85 (Broncho-Vaxom®, Broncho-Munal®, Ommunal®, Paxoral®, Vaxoral®) is known to protect against recurrent respiratory tract infections. Despite mechanistic investigations performed during clinical and pre-clinical studies, little is known regarding the initial immune response to OM-85 following its passage through the stomach. To better understand the primary steps in the OM-85 gut-mediated immune-response cascade, we investigated its effects on two candidate cell types: intestinal epithelial cells (IECs) and Peyer’s patch (PP) leukocytes and confirmed its sustained immune effect in a reconstituted gastric buffer. Methods: In order to confirm OM-85’s continued activity following gastric transit, THP-1 cells.. View More»
  DOI: 10.4172/2155-9899.1000494

  Abstract PDF

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