Journal of Clinical and Cellular Immunology

Journal of Clinical and Cellular Immunology
Open Access

ISSN: 2155-9899

Charles J Malemud

Charles J Malemud
Case Western Reserve University School of Medicine,
University Hospitals Cleveland Medical Center, Foley Medical Building, 2061 Cornell Road, Room 207, Cleveland, Ohio 44106-5076

  • Review Article
    Immunomodulators in Autoimmunity and Viral Infections
    Author(s): Charles J MalemudCharles J Malemud

    Immunologically-based therapies are steadily moving from the laboratory to clinical practice. In that regard, the elevated levels of “immunocytokine” gene expression, including, tumor necrosis factor-α, various interleukins, cytotoxic T-cell antigen-4, B-cell activating factor, and others, are characteristic of autoimmune diseases, such as rheumatoid arthritis, inflammatory bowel diseases, psoriatic arthritis and system lupus erythematosus and, some cancers as well. Treatment of these autoimmune diseases with first-line Immunologically-based therapies can ameliorate the pathology associated with autoimmunity and cancer and, can also inhibit transplant rejection. Importantly, drugs containing immunomodulatory activity are now also known to have significant and effective anti-viral activity which may result from their role in reducing the impact of “immunocytokin.. Read More»
    DOI: 10.4172/2155-9899.1000537

    Abstract PDF

Relevant Topics