Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Charles J Malemud
Case Western Reserve University School of Medicine,
University Hospitals Cleveland Medical Center, Foley Medical Building, 2061 Cornell Road, Room 207, Cleveland, Ohio 44106-5076
Tanzania
Review Article
Immunomodulators in Autoimmunity and Viral Infections
Author(s): Charles J Malemud
Charles J Malemud
Immunologically-based therapies are steadily moving from the laboratory to clinical practice. In that regard, the elevated levels of “immunocytokine” gene expression, including, tumor necrosis factor-α, various interleukins, cytotoxic T-cell antigen-4, B-cell activating factor, and others, are characteristic of autoimmune diseases, such as rheumatoid arthritis, inflammatory bowel diseases, psoriatic arthritis and system lupus erythematosus and, some cancers as well. Treatment of these autoimmune diseases with first-line Immunologically-based therapies can ameliorate the pathology associated with autoimmunity and cancer and, can also inhibit transplant rejection. Importantly, drugs containing immunomodulatory activity are now also known to have significant and effective anti-viral activity which may result from their role in reducing the impact of “immunocytokin.. View More»
DOI:
10.4172/2155-9899.1000537