Journal of Clinical and Cellular Immunology

Journal of Clinical and Cellular Immunology
Open Access

ISSN: 2155-9899

Charles J Malemud

Charles J Malemud
Division of Rheumatic Diseases,
Foley Medical Building, 2061 Cornell Road, Rm. 207, Cleveland, Ohio 44106-5076

  • Review Article
    Intracellular Signaling Pathways in Rheumatoid Arthritis
    Author(s): Charles J MalemudCharles J Malemud

    Dysfunctional intracellular signaling involving deregulated activation of the Janus Kinase/Signal Transducers and Activators of Transcription (JAK/STAT) and “cross-talk” between JAK/STAT and the stress-activated protein kinase/mitogen-activated protein kinase (SAPK/MAPK) and Phosphatidylinositide-3-Kinase/AKT/mammalian Target of Rapamycin (PI-3K/AKT/mTOR) pathways play a critical role in rheumatoid arthritis. This is exemplified by immune-mediated chronic inflammation, up-regulated matrix metalloproteinase gene expression, induction of articular chondrocyte apoptosis and “apoptosis-resistance” in rheumatoid synovial tissue. An important consideration in the development of novel therapeutics for rheumatoid arthritis will be the extent to which inhibiting these signal transduction pathways will sufficiently suppress immune cell-mediated inflammation to produce a .. Read More»
    DOI: 10.4172/2155-9899.1000160

    Abstract PDF

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