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Journal of Clinical and Cellular Immunology

Journal of Clinical and Cellular Immunology
Open Access

ISSN: 2155-9899

+44 1223 790975

Charles J. Malemud

Charles J. Malemud

Foley Medical Building, 2061 Cornell Road, Cleveland, Ohio 44106-5076
Tanzania

Publications
  • Review Article
    Apoptosis Resistance in Rheumatoid Arthritis Synovial Tissue
    Author(s): Charles J. MalemudCharles J. Malemud

    The pathogenesis of rheumatoid arthritis (RA) evolves from deregulated cellular and humoral immunity resulting in a chronic and systemic inflammatory response. Perpetuating the sustained inflammation in RA synovial joints requires the migration and retention of activated T-lymphocytes, B-lymphocytes, mast cells, neutrophils and antigen presenting cells. The synovial tissue becomes hyperplastic as a result of unrestrained synoviocyte proliferation and the resistance of synoviocytes, immune and inflammatory cells to apoptosis. Synoviocyte proliferation is mainly sustained by the elevated levels of pro-inflammatory cytokines in the RA synovial joint milieu. Thus, proinflammatory cytokines, including tumor necrosis factor-α, interleukin-(IL)-1β and IL-6, IL-17, interferon-γ, among others, predominantly activate the stress-activated protein kinase/mitogen-activated protein k.. View More»
    DOI: 10.4172/2155-9899.S3-006

    Abstract PDF

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