Journal of Thyroid Disorders & Therapy

Journal of Thyroid Disorders & Therapy
Open Access

ISSN: 2167-7948

Catherine Ronin

Catherine Ronin
Morandat Technological Hotel,
1480 Armenia Street, 13120 Gardanne

  • Research Article
    New Immunoassays of Bioactive TSH Improve Detection of Thyroid Disorders
    Author(s): Sandrine Donadio-Andréi and Catherine RoninSandrine Donadio-Andréi and Catherine Ronin

    Background: TSH assays have long been showing discordances, especially in the upper limit of the reference range. There is thus a need to improve TSH measurement and detection of thyroid dysfunction. This study aimed at evaluating the ability of new TSH assays to detect early thyroid deficiency in a healthy population with no suspicion of thyroid disorders. Methods: We selected 797 subjects without declared hyperthyroidism, hypothyroidism, goiter, personal or familial thyroid dysfunction, thyroid autoimmunity or medication among 1,623 individuals recruited in a multicenter prospective study (2012-2014). Hypothyroidism-related clinical signs (hCS) were collected, TSH and thyroid hormones levels measured by routine tests and 4 new assays based on calibration with a biologically active recombinant TSH. Analysis was performed as a function of ge.. View More»
    DOI: 10.4172/2167-7948.1000223

    Abstract PDF

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