Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Carolyn Sweeney
Tanzania
Research Article
Bcl-2-expression in Dys-regulated Distribution of T and B Lymphocytes in Aged Mice
Author(s): Yongxin Zhang, Monica Zhang, Ying Wang, Lin Liu, Carolyn Sweeney, Lifang Tian and Innocent N Mbawuike
Yongxin Zhang, Monica Zhang, Ying Wang, Lin Liu, Carolyn Sweeney, Lifang Tian and Innocent N Mbawuike
The expression of Bcl-2 in peripheral blood lymphocytes in aged mice was assessed using flow cytometry and compared with young mice. The results showed that the frequencies of CD3+, CD4+ and CD8+ cells and the frequencies of CD3+, CD4+ and CD8+ cells expressing Bcl-2 were decreased in aged mice. Bcl-2 expression in T cells was positively correlated with frequencies of each sub-population of T cells but negatively correlated with age (old and young). In contrast, the frequencies of B cells (CD19+) and Bcl-2+ B cells in total lymphocytes as well as Bcl-2 positive rate in CD19+ B cells were all increased in old mice. The mouse age, CD19+ cell frequency and Bcl-2+ B cell frequency were positively correlated each other. These results suggest that Bcl-2 expression on T an.. View More»
DOI:
10.4172/2155-9899.1000473