Andrology-Open Access
Open Access
ISSN: 2167-0250
+44 1300 500008
ISSN: 2167-0250
+44 1300 500008
Carol A. Podlasek
M/C 955 820 S. Wood St.,
CSN 515, Chicago, IL 60612
Tanzania
Research Article
Effect of Onabotulinum Toxin A on Substance P and Receptor Neurokinin 1 in
the Rat Ventral Prostate
Author(s): Omer Onur Cakir, Carol A. Podlasek, Douglas Wood, Kevin E. McKenna and Kevin T. McVaryOmer Onur Cakir, Carol A. Podlasek, Douglas Wood, Kevin E. McKenna and Kevin T. McVary
Introduction: The objective of this work is to examine if sensory innervation impacts lower urinary tract symptoms (LUTS). Onabotulinum toxin A (BoNTA) has been used for the treatment of overactive and neurogenic bladder and as a treatment for LUTS secondary to benign prostatic hyperplasia (BPH). The mechanism of how BoNTA impacts LUTS/BPH is unclear. In rats, BoNTA injection causes prostate denervation, apoptosis and atrophy. In clinical trials reduced prostate size and LUTS are observed inconsistently, suggesting a neurologic component. We will examine if BoNTA treatment inhibits substance P production in sensory nerve fibers in the rat prostate. Methods: Twenty Sprague Dawley rats were divided into four groups including 1X PBS (control, n=6), 2.5 units Onabotulinum toxin A (BoNTA, n=6), 5 units BoNTA (n=6) injected into both lobes of the ventral prostate (VP) and sham surgery (n=2).. View More»
DOI:
10.4172/2167-0250.1000131