Journal of Clinical Chemistry and Laboratory Medicine
Open Access
ISSN: 2736-6588
+44 1223 790975
ISSN: 2736-6588
+44 1223 790975
Bikila Nagasa
Directorate of National Laboratories Capacity Building, Ethiopian Public Health Institute,
Addis Ababa
Ethiopia
Research Article
Application of Cancer Antigen 125 Test in Diagnosis of Pulmonary
Tuberculosis
Author(s): Bikila Nagasa, Atsbeha Gebreegziabxier, Feyissa Challa, Meron Silashi, Zeleke Geto, Tigist Getahun, Genet Ashebir, Abenezer Ayalkebet, Tadesse Lejisa, Yosef Tolcha, Demiraw Bikila, Wossene Habtu and Desta KassaBikila Nagasa, Atsbeha Gebreegziabxier, Feyissa Challa, Meron Silashi, Zeleke Geto, Tigist Getahun, Genet Ashebir, Abenezer Ayalkebet, Tadesse Lejisa, Yosef Tolcha, Demiraw Bikila, Wossene Habtu and Desta Kassa
Objective: Cancer antigen125 (CA-125) test is the most frequently used biomarker for ovarian cancer, but according to some literatures CA125 test can discriminate active pulmonary tuberculosis from inactive cases in tuberculosis (TB) patients. Therefore the objective of this work was to further study application of CA-125 test in identification of active tuberculosis from inactive cases and for evaluation of response to anti-TB treatment.
Methods: Plasma CA125 of 30 patients with active tuberculosis cases (group 1), 19 cases with inactive tuberculosis (group 2) and 28 healthy subjects (group 3) was measured and compared. Measurement of CA-125 was done only once in group 2 and 3 but it was repeated in group 1 at two and six month of anti-TB treatment. Independent t-test was used to compare CA125 level between groups and paired t-test was used to.. View More»