Clinical & Experimental Cardiology
Open Access
ISSN: 2155-9880
+44 1300 500008
ISSN: 2155-9880
+44 1300 500008
Benjamin D. Horne
Intermountain Heart Institute, 5121 S. Cottonwood St. Salt Lake City, UT 84107,
Tanzania
Research Article
Association of Chromosome 9p21.3 with Disease Location, Including the Number of Diseased Vessels, but not with Greater Burden of Coronary Disease
Author(s): Benjamin D. Horne, John F. Carlquist, Daniel J. Rader, Joseph B. Muhlestein, John A. Huntinghouse, Muredach P. Reilly and Jeffrey L. AndersonBenjamin D. Horne, John F. Carlquist, Daniel J. Rader, Joseph B. Muhlestein, John A. Huntinghouse, Muredach P. Reilly and Jeffrey L. Anderson
Introduction: Single nucleotide polymorphisms (SNPs) at chromosome 9p21.3 do not influence myocardial infarction, but their role in coronary artery disease (CAD) progression, burden, and outcomes is controversial. This study evaluated whether rs1333049 impacts CAD burden.
Methods: Non-diabetic CAD patients enrolled in the Intermountain Heart Collaborative Study (N=1,757) were evaluated for association of rs1333049 with the Duke CAD Index (primary endpoint) and other CAD measures. Multivariable regression adjusted for potential confounders. Statistical significance of secondary endpoints was corrected for multiple comparisons.
Results: No association of rs1333049 with Duke CAD Index was found for 0, 1, and 2 C alleles: 42.4 ± 16.1, 44.0 ± 17.4, 47.4 ± 17.6, respectively (p-trend=0.12, adjusted p-trend=0.1.. View More»
DOI:
10.4172/2155-9880.S1-005