Journal of Cancer Science and Research
Open Access
ISSN: 2576-1447
+44 1478 350008
ISSN: 2576-1447
+44 1478 350008
Atmodjo WL
Faculty of Medicine, Universitas Pelita Harapan Jl,
Boulevard Jend Sudirman Road 1688, Lippo Karawaci, Tangerang 15811
Indonesia
Research Article
Curcuminoids Suppress the Number of Transformed-Hepatocytes and Ki67 Expression in Mice Liver Carcinogenesis Induced by Diethylnitrosamine
Author(s): Atmodjo WL, Larasati YO, Isbandiati D and Mathew GAtmodjo WL, Larasati YO, Isbandiati D and Mathew G
Background: Curcuminoids has been reported to have strong anti-oxidant and anti-inflammatory effects, however the effect of curcuminoids to hepatocytes and their proliferation in DEN (Diethylnitrosamine) induced mice liver carcinoma model is still not yet been studied in detail.
Objection: To evaluate the effects of curcuminoids-containing diets in liver carcinoma mice induce with Diethylnitrosamine
Methods: Forty of 5 weeks old, male Balb/C mice were administered DEN as an injection and fed with basal diet; and another group injected with DEN and fed with 0.2% curcuminoids-containing diet. Dose of injection DEN is 75 mg/kg BW/week for 3 weeks, continued with 100 mg/kg BW/week for 3 continuous weeks. Five animals in each group were sacrificed at 20 and 32 weeks after the first injection of DEN. The liver sections were st.. View More»
DOI:
10.4172/2576-1447.1000112