Immunome Research
Open Access

Aotsuka A

Publications

• Research Article
  Serum SH3BP5-specific Antibody Level is a Biomarker of Atherosclerosis
  Author(s): Hiwasa T, Tomiyoshi G, Nakamura R, Shinmen N, Kuroda H, Kunimatsu M, Mine S, Machida T, Sato E, Takemoto M, Hattori A, Kobayashi K, Kawamura H, Ishibashi R, Yokote K, Kitamura K, Ohno M, Chen PM, Nishi E, Ono K, Kimura T, Takizawa H, Kashiwado K, Kamitsukasa I, Wada T, Aotsuka A, Sunami K, Kobayashi E, Yoshida Y, Matsutani T, Iwadate Y, Mori M, Uzawa A, Muto M, Sugimoto K, Kuwabara S, Iwata Y, Kobayashi Y, Terada J, Matsumura T, Sakao S, Tatsumi K, Ito M, Shimada H, Zhang XM, Kimura R, Wang H, Iwase K, Ashino H, Taira A, Arita E, Goto K and Doi HHiwasa T, Tomiyoshi G, Nakamura R, Shinmen N, Kuroda H, Kunimatsu M, Mine S, Machida T, Sato E, Takemoto M, Hattori A, Kobayashi K, Kawamura H, Ishibashi R, Yokote K, Kitamura K, Ohno M, Chen PM, Nishi E, Ono K, Kimura T, Takizawa H, Kashiwado K, Kamitsukasa I, Wada T, Aotsuka A, Sunami K, Kobayashi E, Yoshida Y, Matsutani T, Iwadate Y, Mori M, Uzawa A, Muto M, Sugimoto K, Kuwabara S, Iwata Y, Kobayashi Y, Terada J, Matsumura T, Sakao S, Tatsumi K, Ito M, Shimada H, Zhang XM, Kimura R, Wang H, Iwase K, Ashino H, Taira A, Arita E, Goto K and Doi H
  
  Abstract Background: The discovery and development of novel biomarkers that could facilitate early diagnosis and thus prevent the progression of atherosclerosis-related diabetes mellitus (DM), cerebral infarction (CI), and cardiovascular disease (CVD) has garnered much research interest. Notably, recent reports have described a number of highly sensitive antibody markers. In this study, we aimed to identify additional antibody markers that would facilitate screening. Methods: The amplified luminescent proximity homogeneous assay (AlphaLISA) method, which incorporates glutathione- or streptavidin-donor beads and anti-human-IgG-acceptor beads, was used to evaluate serum antibody levels in serum samples. The protein array method was used for the initial screening, and peptide arrays were used to identify epitope sites. Results: The protein array identified SH3 domain-binding protein 5 (S.. View More»
  DOI: 10.4172/1745-7580.10000132

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