Journal of Fertilization: In Vitro - IVF-Worldwide, Reproductive Medicine, Genetics & Stem Cell Biol
Open Access
ISSN: 2375-4508
+44 7868 792050
ISSN: 2375-4508
+44 7868 792050
Antonio Maselli
Centro Fecondazione Assistita, Clinica Villa del Sole,
Via Manzoni 15, 80122 Napoli
Italy
Research Article
Controlled Ovarian Hyperstimulation through Gonadotrophin releasing Hormone Agonist for Patients at Risk of Hyperstimulation Syndrome
Author(s): Antonio Maselli, Martin Wilding, Sylvia del Grande, Stefania Riccio, Loredana Di Matteo and Brian DaleAntonio Maselli, Martin Wilding, Sylvia del Grande, Stefania Riccio, Loredana Di Matteo and Brian Dale
Background:Patients at high risk of OHSS can experience difficulty in completing an IVF cycle with the administration of gonadotrophins. Here, we test a unique low-dose GnRH agonist protocol.
Methods: 0.1mg triptorlin acetate (decapeptyl) was administered to 18 patients at high risk of OHSS from day 5 of the menstrual cycle. Oocyte retrieval was performed 36 hours after the administration of 10000 IU human chorionic gonadotrophin, when follicles of 18-20mm were observed. Oocytes were fertilised in vitro and embryos transferred on day 3.
Results: Patients produced a mean of 4.1 ± 0.96 oocytes. After ICSI, a mean of 3.0 ± 0.84 embryos were transferred to the uterus. A total of 5 pregnancies were obtained from the 18 cycles. No patients were affected by OHSS.
Conclusions: Low-dose inject.. View More»
DOI:
10.4172/2165-7491.1000103