Andrology-Open Access
Open Access
ISSN: 2167-0250
+44 1300 500008
ISSN: 2167-0250
+44 1300 500008
Annapia Verri
Laboratory of Cognitive-Behavioral Psychology,
Fondazione IRCCS Istituto, Neurological Casimiro Mondino, Pavia
Italy
Research Article
Variability in Cognitive Behavioral Phenotypes in Klinefelter Syndrome (KS)
and Other Sex Chromosomal Aneuploidies (SCAs)
Author(s): Annapia Verri, D’Angelo Carmen, Cremante Anna, Clerici Federica, Mauri Anna and Castelletti ChiaraAnnapia Verri, D’Angelo Carmen, Cremante Anna, Clerici Federica, Mauri Anna and Castelletti Chiara
Sex Chromosomal Aneuploidies (SCAs) are the most frequently occurring chromosomal abnormalities with an incidence of 1 in 450 births. Males with SCAs are known to have variability in their developmental profile. Aim of this paper is to illustrate clinical variability in the different SCAs. The sample was composed by 53 subjects (mean age=21.16 years, range: 13-54) with karyotype 47, XXY (73%), 49, XXXXY (7%), 48, XXYY (9%), mosaicism 47, XXY/48, XXXY (2%), 47, XYY (5%), 48, XXXY (2%), 49, XXXYY (2%). Only 5 subjects have been diagnosed prenatally (4 KS and 1 XXYY). Primary caregivers completed a comprehensive questionnaire detailing birth, medical, developmental and psychological history. Cognitive and behavioral assessment was performed with clinical interviews with DSM IV criteria and psychometric questionnaires (WISC-R, WAIS-R, CPM, Token Test, VABS, SCL90, and SCQ). Twenty-one sex.. View More»
DOI:
10.4172/2167-0250.1000175