Andrology-Open Access
Open Access
ISSN: 2167-0250
+44 1300 500008
ISSN: 2167-0250
+44 1300 500008
Andre Chan
Tanzania
Research Article
Treatment with a Combination of Ginger, L-Citrulline, Muira Puama and
Paullinia cupana can Reverse the Progression of Corporal Smooth Muscle
Loss, Fibrosis and Veno-Occlusive Dysfunction in the Aging Rat
Author(s): Monica G Ferrini, Su M Hlaing, Andre Chan and Jorge N ArtazaMonica G Ferrini, Su M Hlaing, Andre Chan and Jorge N Artaza
Aims: Aging associated erectile dysfunction is characterized within the corpora by a progressive apoptosis of the smooth muscle cells and their replacement by collagen. Nitric oxide from iNOS has been shown to inhibit these histological changes in the corpora while PDE5 inhibitors as well as certain nutraceuticals such as ginger, paullinia cupana, muira puama and L-citrulline are known to enhance the effects of NO. We evaluated whether the daily oral administration for 2 months with a combination of ginger, paullinia cupana, muira puama and L-citrulline (COMP-4) can effectively delay the ongoing corporal fibrosis, smooth muscle cell apoptosis and Cavernosal Yeno-Occlusive Dysfunction (CVOD) seen in middle aged rats similar to that seen with tadalafil. Methods: 10 Month old Fisher 344 rats were treated or not for two months with COMP-4, tadalafil or a combination of tadalafil plus COMP.. View More»