Journal of Physical Chemistry & Biophysics

Journal of Physical Chemistry & Biophysics
Open Access

ISSN: 2161-0398

Anatoly B

Anatoly B
Institute of Chemical Physics, Russian Academy of Sciences,
Russian Federation

  • Review Article
    Magnetic Control of the DNA Synthesis by Nuclear Magnetic Ions of Mg, Ca and Zn as a Powerful and Universal Means to Kill Cancer Cells
    Author(s): Anatoly B and Dmitry KAnatoly B and Dmitry K

    DNA synthesis is commonly accepted to occur as a nucleophilic reaction catalyzed by Zn2+, Ca2+ and Mg2+ ions. The substitution of these ions with nonmagnetic nuclei by ions with magnetic nuclei was shown to produce a huge isotope effect: magnetic ions suppress DNA synthesis by 3–5 times with respect to nonmagnetic ones. This observation unambiguously evidences that the DNA synthesis occurs by radical pair mechanism, which is well known in chemistry and implies pair wise generation of radicals by electron transfer between reaction partners. Magnetic field dependence of the DNA synthesis convincingly proves radical pair mechanism, which manifests itself even in the polymerase chain reaction. This mechanism, being on the energy scale by order of magnitude cheaper that the nucleophilic one, is switched on, when at least two ions enter into the catalytic site. It coexists with nucleo.. Read More»
    DOI: 10.4172/2161-0398.1000272

    Abstract PDF

Relevant Topics