Journal of Oceanography and Marine Research
Open Access
ISSN: 2572-3103
+44 1300 500008
ISSN: 2572-3103
+44 1300 500008
Ana M. L. Seca
Portugal
Research Article
Chemical Study and Biological Activity Evaluation of Two Azorean Macroalgae: Ulva rigida and Gelidium microdon
Author(s): Madalena Silva, Luís M. M. Vieira, Ana Paula Almeida, Artur M. S. Silva, Ana M. L. Seca, M. Carmo Barreto, Ana I. Neto, Madalena Pedro, Eugénia Pinto and Anake KijjoaMadalena Silva, Luís M. M. Vieira, Ana Paula Almeida, Artur M. S. Silva, Ana M. L. Seca, M. Carmo Barreto, Ana I. Neto, Madalena Pedro, Eugénia Pinto and Anake Kijjoa
The green macroalga Ulva rigida C. Agardh (Chlorophyta) and the red macroalga Gelidium microdon Kützing (Rhodophyta), collected from the Azorean archipelago, were investigated for their secondary metabolites and their in vitro growth inhibitory effect on three human tumor cell lines: MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer) and A375-C5 (melanoma), as well as for their antifungal and antibacterial activities. The methanol extract of U. rigida furnished isofucosterol (1), 7(E)-3β-hydroxy-5α,6α-epoxymegastigmane (2) and (+)-dehydrovomifoliol (3) while the methanol extract of G. microdon yielded cholesterol (4) and lumichrome (5). The crude extracts of both macroalgae were found to be moderately active against the three cell lines whereas compound 1 showed a weak effect and compound 2 was inactive. The c.. View More»
DOI:
10.4172/2332-2632.1000102