Organic Chemistry: Current Research
Open Access
ISSN: 2161-0401
+44 1478 350008
ISSN: 2161-0401
+44 1478 350008
Amira A Ghoneim
Zagazig, EG-44519
Egypt
Research Article
Synthesis of Some Novel Fused Heterocyclic Compounds Derivatives from Bis-chalcones
Author(s): Amira A Ghoneim and Ahmed F El-FarargyAmira A Ghoneim and Ahmed F El-Farargy
A chalcone was prepared by the reaction of 1,4-diacetylbenzene with benzaldehyde. Reaction of this chalcone with cynanothioacetamide/guanidine hydrochloride and malnonitrile in presence of piperdene afforded the corresponding pyridine, pyrimidine, and pyrans derivatives in good yields respectively. Further, bis-chalcone 1 was cyclized to pyrazole analogs by using thiosemicarbazide, semicarbazide and tertiarybutylcarbazate. The newly heterocyclic compounds have been characterized by IR, 1H-NMR and elemental analyses... View More»