Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
+44 1223 790975
ISSN: 2155-9899
+44 1223 790975
Ameera Kamal Khalil
College of Dentistry,
Erbil, Iraqi Kurdistan
Iraq
Research Article
Effect of Chamomile Extract on the Tongue of Chemotherapy Treated Albino Rats (Histopathological and Immunohistochemical Study)
Author(s): Ali Sultan Al-Refai, Othman A. Omar and Ameera Kamal KhalilAli Sultan Al-Refai, Othman A. Omar and Ameera Kamal Khalil
Background and objectives: 5-Fluorouracil (5-FU) is a commonly used drug for the treatment of malignant cancers. The control of oral mucositis result from 5-FU use is becoming increasingly more important, and effective intervention is considered a high priority in cancer patient care. The aim of this study was to investigate the effect of chamomile extract on the pathogenesis of 5-FU induced tongue mucositis in Albino rat.Materials and methods: In current study forty female Albino rats, weighing 220-280 g were used. For the induction of mucositis, 60 mg/kg of 5-FU was administered intraperitoneally to each animal in the study group on day 0, and 40 mg/kg was administered on day 2. The control animals were intraperitoneally injected by normal saline in the same manner and dose like 5-FU on day 0 and 2. Then the rats in each group were randomly di.. View More»
DOI:
10.4172/2155-9899.1000251