Journal of Clinical and Cellular Immunology

Journal of Clinical and Cellular Immunology
Open Access

ISSN: 2155-9899

+44 1223 790975

Ali Sultan Al-Refai

Ali Sultan Al-Refai
College of Dentistry,
Erbil, Kurdistan

  • Research Article
    Immunohistochemical Study of the Effect of Chamomile Extract on 5-Fluorouracil Induced Intestinal Mucositis in Albino Rats
    Author(s): Ali Sultan Al-RefaiAli Sultan Al-Refai

    Background and objectives: 5-Fluorouracil (5-FU) is a commonly used drug for the treatment of malignant cancers. Approximately 80% of patients undergoing 5-FU treatment suffer from gastrointestinal mucositis. The aim of this study was to investigate the effect of chamomile extract on the pathogenesis of 5-FU induced intestinal mucositis in Albino rat.Materials and methods: In current study forty females Albino rats, weighing 220-280 g were used in the study. For the induction of mucositis, 60 mg/kg of 5-FU was administered intraperitoneally to each animal in the study group on day 0, and 40 mg/kg was administered on day 2. The control animals were intraperitoneally injected by normal saline in the same manner and dose like 5-FU on day 0 and 2. Then the rats in each group were randomly divided into two groups: Distilled water treated group and ch.. View More»
    DOI: 10.4172/2155-9899.1000232

    Abstract PDF

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