Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Alejandro Javier Español
Argentina
Research Article
Cholinergic Actions of Autoantibodies from Breast Cancer Patients on Dendritic Cells
Author(s): Maria Gabriela Lombardi, Gabriela Salamone, Soledad Gori, Manuel Alejandro Orono, Alejandro Javier Espanol and Maria Elena SalesMaria Gabriela Lombardi, Gabriela Salamone, Soledad Gori, Manuel Alejandro Orono, Alejandro Javier Espanol and Maria Elena Sales
Autoantibodies (autoAbs) against self-proteins have been localized in tumor microenvironment exerting a complex network of interactions. We reported the presence of autoAbs in breast cancer patients, which promote tumor progression by activating muscarinic acetylcholine receptors (mAChR) in tumor cells. Cholinergic receptors are also expressed in dendritic cells (DC) and much clear evidence demonstrated a deficient functional activity of DC in cancer. Here we investigated whether autoAbs can modulate the expression of maturation markers and the production of cytokines by DC. IgG from breast cancer patients in stage I reduced the expression of HLA-DR and CD86 as well as tumor necrosis factor alpha liberation and augmented interleukin IL-12 and IL-10 levels by cholinergic activation of mature DC. The latter cytokines are also up-regulated in patients’ .. View More»
DOI:
10.4172/2155-9899.1000340