Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
+44 1223 790975
ISSN: 2155-9899
+44 1223 790975
Aaron Lerner
AESKU.KIPP Institute,
Mikroforum Ring 2, Wendelsheim 55234
Germany
Research Article
Comparison of the Reliability of 17 Celiac Disease Associated Bio-Markers to Reflect Intestinal Damage
Author(s): Aaron Lerner, Patricia Jeremias, Sandra Neidhöfer and Torsten MatthiasAaron Lerner, Patricia Jeremias, Sandra Neidhöfer and Torsten Matthias
In view of the increasing importance of serological biomarkers for screening and diagnosing celiac disease (CD) and the lack of back-to-back comparison of their differential performance to their reliability to reflect the intestinal damage in children with CD, their performances were evaluated.
95 pediatric CD patients (mean age 8.3), 45 nonspecific abdominal pain children (AP) (mean age 7.3), 99 normal children (NC) (mean age 8.5) were tested with following ELISAs (detecting IgA, IgG or both, IgA and IgG (check)): AESKULISA® Gliadin (AGA), AESKULISA® DGP (DGP), AESKULISA® tTg “New Generation” (Neo-epitope tTg complexed to gliadin=tTg-neo), tTg (for in house research purpose only), AESKULISA® mTg neo-epitope and mTg (RUO). Anti-endomysial antibodies (EMA) were checked via.. View More»
DOI:
10.4172/2155-9899.1000486