Journal of Clinical and Cellular Immunology

Journal of Clinical and Cellular Immunology
Open Access

ISSN: 2155-9899

+44 1223 790975

Aaron Lerner

Aaron Lerner
AESKU.KIPP Institute, Mikroforum ring 2,
Wendelsheim 55234

  • Review Article
    GUT-the Trojan Horse in Remote Organs Autoimmunity
    Author(s): Aaron Lerner and Torsten MatthiasAaron Lerner and Torsten Matthias

    Human beings assemble and maintain a diverse but host-specific gut microbial community along the longitudinal axis of the intestines. Helped by a functional tight junction, the default response to commensal microbes is tolerance, whereas the default response to pathogens is an intricately orchestrated immune response, resulting in pathogen clearance. Nutrients and industrial food additives were suggested to impact the intestinal ecosystem and to breach tight junction integrity. Taken together, certain nutritional components, increased intestinal permeability, disease specific dysbiotic pathobionts and their capacity of post translation modification of proteins, are luminal events that impact autoimmunogenesis. The present review expands on the multi gut originated axes and their relationship to remote organ autoimmune diseases. Brain, joint, bone, endocrine, liver, kidney, heart, lung.. View More»
    DOI: 10.4172/2155-9899.1000401

    Abstract PDF

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